1995年获中国驻日大使馆教育处优秀留学人员称号，大自的更同年获国家杰出青年科学基金资助。

然比【小结】自组装纳米材料现已广泛用于纳米医学领域。然而，象中在复杂的生理条件下，预组装的纳米材料的超结构和性质会有些受损。

神奇图八：形态转变抑制肿瘤转移（a）BP-KRYNPs转化为BP-KRYNFs构建人工细胞外基质以抑制肿瘤转移的示意图。大自的更图三：热响应聚合物调控的BP自组装及应用（a）用于监测和操纵HER2受体聚集的细胞表面上BP自组装的热控制的示意图。然比（c）在365nm下不同pH下BP分散的PbAE胶束的荧光光谱和图像。

象中（c）4天后通过TEM观察有/无Ca2+条件下BP-KR的结构转化。文献链接：神奇Bispyrene-BasedSelf-AssembledNanomaterials:InVivoSelf-Assembly,Transformation,andBiomedicalEffects(Acc.Chem.Res.,2019,DOI:10.1021/acs.accounts.8b00398)关于BP分子的相关文献：神奇1.HongqianCao,YanfeiQi,YangYang,*LeiWang,JiahengSun,YueLi,JiaruiXia,HaoWangandJunbaiLi*,AssembledNanocomplexforImprovingPhotodynamicTherapythroughIntraparticleFluorescenceResonanceEnergyTransfer,Chem.AsianJ.,2018,13(22),3540-3546.2.Pei-PeiYang,ChaoYang,KuoZhang,LeiWang,*andHaoWang*KLVFFPeptideFunctionalizedNanoparticlesCaptureAβ42byCo-AssemblyforDecreasingCytotoxicity,2018Inpress.3.Bing-NanLi,Ping-PingHe,Pei-PeiYang,Jing-PingZhang,*LeiWang*andHaoWang*,Insituconstructionofnano-networksfromtransformablenanoparticlesforanti-angiogenictherapy,J.Mater.Chem.B,J.Mater.Chem.B,2018,6,5282-5289.4.QiangLuo,#Yao-XinLin,#Pei-PeiYang,#YiWang,Guo-BinQi,Zeng-YingQiao,Bing-NanLi,KuoZhang,Jing-PingZhang,*LeiWang*andHaoWang*,ASelf-destructiveNanosweeperthatCapturesandClearsAmyloidβ-Peptides,NatureCommun.,2018,9,1802.讲工作5.Guo-BinQi,Yu-JuanGao,LeiWang*andHaoWang*,Self-AssembledPeptide-BasedNanomaterialsforBiomedicalImagingandTherapy,Adv.Mater.,2018,30(22),1703444.6.HongqianCao,LeiWang,YangYang,*JuanLi,YanfeiQi,YueLi,YingLi,HaoWangandJunbaiLi*,AnAssembledNano-complexforImprovingbothTherapeuticEfficiencyandTreatmentDepthinPhotodynamicTherapy,Angew.Chem.,Int.Ed.2018,57(26),7759-7763.7.Yao-XinLin,#Xue-FengHu,#YangZhao,#Yu-JuanGao,ChaoYang,Sheng-LinQiao,JiaoYan,Pei-PeiYang,QianZeng,Zeng-YingQiao,Li-LiLi,Jiang-BingXie,Si-QuanZhu,Xiao-ChunWu,LeiWang*andHaoWang*,IntraocularLenswithAmorphousNanostructuredRimforHigh-EfficientEye-DiseaseTreatment,Adv.Mater.,2017,29(34),1701617.8.Pei-PeiYang,#QiangLuo,#Guo-BinQi,#Yu-JuanGao,Bing-NanLi,Jing-PingZhang,LeiWang*andHaoWang*,HostMaterialsTransformableinTumorMicroenvironmentforHomingTheranostics,Adv.Mater.,2017,29(15),1605869.9.Yao-XinLin,Sheng-LinQiao,YiWang,Ruo-XinZhang,Hong-WeiAn,Zeng-YingQiao,LeiWang*andHaoWang*,AninsituIntracellularSelf-AssemblyStrategyforQuantitativeandTemporalMonitoringAutophagy,ACSNano,2017,11(2),1826-1839.10.Xiao-XueHu,Guo-BinQi,Yu-JuanGao,Yao-XinLin,ChaoYang,Pei-PeiYang,Hong-XunHao*,LeiWang*andHaoWang*,ArtificialExtracellularMatrixBasedonTransformableNanomaterialsforHigh-EfficientInhibitionofTumorInvasionandMetastasis,ACSNano,2017,11(4),4086-4096.11.BingbingSun,LeiWang,QiLi,PingpingHe,HuilingLiu,HaoWang,YangYang,*JunbaiLi*,Bis(pyrene)DopedCationicDipeptideNanoparticlesforTwo-Photon-ActivatedPhotodynamicTherapy,Biomacromolecules,2017,18(11),3506-3513.12.Hong-WeiAn,Sheng-LinQiao,Li-LiLi,ChaoYang,Yao-XinLin,YiWang,Zeng-YingQiao,LeiWang*andHaoWang*,BioorthogonalReactionDrivesSelectiveSegmentationofComponentsfromNanoaggregatesforSpecificIntracellularBioimaging,ACSAppl.Mater.Interfaces,2016,8(30),19202–19207.13.An-PingXu,#Pei-PeiYang,#ChaoYang,Yu-JuanGao,Xiao-XiaoZhao,QiangLuo,Li-ZhongLi,*LeiWang*andHaoWang*,Bio-InspiredMetalIonsRegulateMorphologicalTransformationofSelf-AssembledPeptide-BasedNanoparticles,Nanoscale,2016,8,14078–14083.14.Pei-PeiYang,#Yun-GangZhai,#Yao-XinLin,Xiao-XiaoZhao,Yu-JuanGao,YangYang,An-PingXu,ChaoYang,Yong-ShengLi,*LeiWang*andHaoWang*,JanusNanoparticleswithActiveMotionbyNIRLightPropulsionforHighEfficientEnhancedPhotothermalTreatment,Small,2016,12(39),5423–5430.15.Sheng-LinQiao,YiWang,Yao-XinLin,Hong-WeiAn,Li-LiLi,LeiWang*andHaoWang*,Thermo-ControlOverSelf-AssemblyofPolymericBis(pyrene)sonCellSurfacesforMonitoringandRegulatingReceptorClustering,ACSAppl.Mater.Interfaces,2016,8(27),17016–17022.16.Pei-PeiYang,Xiao-XiaoZhao,An-PingXu,LeiWang*andHaoWang*,ReorganizationofSelf-AssembledPolymericPeptidesControlledbyHydrogenBondingandHydrophilic/HydrophobicBalance,J.Mater.Chem.B,2016,4,2662–2668.17.Hong-WeiAn,Sheng-LinQiao,Chun-YuanHou,Yao-XinLin,LeiWang*andHaoWang*Self-AssembledNIRNanovesiclesforLong-TermPhotoacousticImagingInVivo,Chem.Commun.,51,13488–13491.18.Zeng-YingQiao,Chun-YuanHou,Wen-JingZhao,DiZhang,Pei-PeiYang,LeiWang*andHaoWang*,SynthesisofSelf-ReportingPolymericNanoparticlesforInSituMonitoringEndocyticMicroenvironmentalpH,Chem.Commun.,51,12609–12612.19.ZhongyuDuan,*Yu-JuanGao,Zeng-YingQiao,ShenglinQiao,YongmeiWang,ChunyuanHou,LeiWang*andHaoWang*,pH-Sensitivepolymerassistedself-aggregationofbis(pyrene)inlivingcellsinsituwithturn-onfluorescence.,Nanotechnology,2015,26,355703.20.Pei-PeiYang,YangYang,Yu-JuanGao,YiWang,Ju-ChenZhang,Yao-XinLin,LuruDai,JunbaiLi,LeiWang*andHaoWang*,UnprecedentedlyHighTissuePenetrationCapabilityofCo-AssembledNanosystemsforTwo-PhotonFluorescenceImagingInVivo,Adv.Optical.Mater.,2015,3(5),646–651.21.WeiLi,Pei-PeiYang,LeiWang*andHaoWang*,Bis-PyreneBasedReversiblyMulti-ResponsiveFluorescenceSwitches,J.Mater.Chem.C.2015,3,3783–3789.22.LeiWang,WeiLi,JingLu,Jing-PingZhang*andHaoWang*Bis-PyreneCarbocationsforChromogenicandFluorogenicDualDetectionofFluorideAnionInSitu,Tetrahedron,2014,70(19),3172–3177.23.WeiLi,#LeiWang,#Jing-PingZhang*andHaoWang*,Bis-Pyrene-BasedSupramolecularAggregateswithReversiblyMechanochromicandVaporchromicResponsiveness,J.Mater.Chem.C,2014,2(10),1887–1892.24.LeiWang,Li-liLi,Yun-shanFanandHaoWang*,Host–GuestSupramolecularNanosystemsforCancerDiagnosticsandTherapeutics,Adv.Mater.,2013,25(28),3888–3898.25.LeiWang,WeiLi,JingLu,Ying-XiZhao,GangFan,Jing-PingZhang*andHaoWang*,SupramolecularNano-AggregatesBasedonBis(Pyrene)DerivativesforLysosome-TargetedCellImaging,J.Phys.Chem.C,2013,117(50),26811–26820.通讯作者简介：王浩研究员，国家纳米科学中心研究员，博士生导师，中国科学院百人计划引进海外杰出人才，国家杰出青年科学基金获得者。

大自的更（e）在活细胞中用于自噬检测的DP-BP的分子结构。

然比图六：亲疏水作用诱导的从NPs到NFs的形态转化（a）BP-KP从单体到NPs到NFs的形态转化的示意图。当狗狗与我们保持步伐一致，象中且注意力在我们人身上的时候，再从食物包里面掏出奖食给予它奖励。

第一步手拿奖食带着狗狗往前走，神奇边走边给小家伙奖励。最后大家就可以增加难度，大自的更过渡到车多人多的地方。

狗吃东西卡牙齿怎么办啊视频中的狗狗是一只金毛，然比这只金毛平时非常温顺，然比不会咬人，但是有一天主人发现它的嘴里有一个小洞，而且还流血了，于是赶紧带它去医院看病。这里我们将奖励的手呈握拳状放于胸口处，象中吸引小家伙的注意力。